11/13/2023 0 Comments Overkill definitionWhat this definition suggests is that overkill requires a 12-D process, which equates to lethality sufficient to deliver a 12 × D 121 lethality level. Unfortunately, it cannot be demonstrated in a straightforward manner with presently available technology. This article focuses on steam sterilization, of which there is both a greater amount of published definitions and a more precise and generally accepted understanding of the underlying science.Ī contemporary definition of overkill moist-heat sterilization follows: "This is usually achieved by providing a minimum 12-log reduction of microorganisms having a D-value of at least one minute at 121 ☌" (1). Confusion associated with the overkill approach exists in all of the widely used sterilization technologies that is, moist heat, dry heat, gas, and radiation. Although this is true, there is substantial confusion about how to use the overkill method and, in fact, regarding what actually constitutes an overkill process. It generally is considered to be the simplest and most straightforward method for the design and validation of moist-heat sterilization processes. Overkill sterilization primarily is applied to the moist-heat processing of materials, supplies, and other heat-stable goods. The overkill method is perhaps the most common method used in the development and validation of sterilization processes. Current sterilization practices are reviewed and the validation difficulties associated with the various definitions of overkill sterilization are explored. The author clarifies the definition and objectives of overkill sterilization for steam sterilization cycles.
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